Separation of Ibuprofen Enantiomers by Diastereomic Salt Formation and Precipitation in Supercritical Carbon Dioxide
نویسندگان
چکیده
The aim of the investigation is to validate the potential of SAS crystallization process to resolve racemic ibuprofen. The resolution is performed via diastereomic salt formation and subsequent salt precipitation in a supercritical CO2 environment. Firstly, the operating conditions, using (S)-α-methylbenzylamine as resolving agent, were optimized. Secondly, the measurement of the binary phase diagram of (S,R)-Ibuprofen and L-Arginine was initiate as a previous step in the assessment of L-Arginine as resolving agent of ibuprofen.
منابع مشابه
Simulation of Separation of a Racemic Mixture of Ibuprofen by Supercritical Fluid Chromatography in Simulated Moving Bed
Separation of a racemic mixture of ibuprofen at a low concentration level by supercritical fluid chromatography in a simulated moving bed (SFC-SMB) is investigated by simulation. The feasibility of ibuprofen enantiomers separation has been experimentally examined in the literature. Our simulation results show that separation of ibuprofen enantiomers is feasible by this method, and R-ibuprofen a...
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